Journal: Critical reviews in therapeutic drug carrier systems

Article Title: Role of Exosomes for Delivery of Chemotherapeutic Drugs

doi: 10.1615/CritRevTherDrugCarrierSyst.2021036301

Figure Lengend Snippet: Drug–loading methods, exosome origin, and delivery of exosomal cargo

Article Snippet: 212 , 213 table ft1 table-wrap mode="anchored" t5 TABLE 1: caption a7 Methods Exosome origin Route Therapeutic Incubation Drugs with cells or drugs with isolated exosomes MSCs (pre–loading) In vitro PTX 189 EL–4 cells Macrophages Intravenous Intranasal Curcumin 190 Curcumin 191 Monocytes/macrophages In vitro DOX 192 Endothelial//tumor In vitro Porphyrin 193 Glioblastoma cells Intravenous siRNA 194 Macrophages In vitro PTX 195 Electroporation Dendritic cells In vitro DOX 196 Macrophages Intravenous/ in vitro PTX 195 Endothelial/tumor In vitro Porphyrin 193 DCs Intravenous siRNA 197 Sonication Macrophages Intravenous/ in vitro PTX 195 HEK 297 and MCF–7 In vitro siRNA 198 ssDNA 199 Macrophages Intranasally Catalase 200 Extrusion Endothelial/tumor In vitro Porphyrin 193 Freeze and thaw cycles Monocyte/macrophage In vitro Catalase/Dox 192 , 193 Open in a separate window Drug–loading methods, exosome origin, and delivery of exosomal cargo Besides small chemotherapeutic drugs, exosomes show good cargo versatility to deliver small nucleic acid and proteins as well.

Techniques: Incubation, Isolation, In Vitro, Electroporation, Sonication